Rewiring Pyroptosis to Potentiate Cancer Immunotherapy via a Gasdermin D Agonist Bypassing Caspase‐3
Dan Zhao, Lingling Zhang, Yue Wen, Lianghui Cheng, Sidan Tian, Fanling Meng, Liang Luo · 2026
Read Rewiring Pyroptosis to Potentiate Cancer Immunotherapy via a Gasdermin D Agonist Bypassing Caspase‐3 by Dan Zhao, Lingling Zhang, Yue Wen, Lianghui Cheng, Sidan Tian, Fanling Meng, Liang Luo (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13393277.txt.
Description
Dan Zhao and six colleagues report a small molecule that forces cancer cells into fiery, immune-alerting death while sidestepping the pathway most such strategies depend on. Many tumours silence the usual executioner route, which runs through caspase-3, and that route's quieter death style can dampen immunity anyway. Their compound, shortened to DIBDO, answers the tumour's abundant glutathione by shedding iodine, which catalytically generates aggressive oxygen and iodine species.
The oxidative burst shuts down upstream caspases, yet directly activates gasdermin D, the pore-forming protein of pyroptosis, so cells burst and spill inflammatory signals. In mouse tumours the treatment drew in killer T cells, teamed with checkpoint blockade to suppress treated and distant tumours alike, and worked as a vaccine that left durable protection. The authors frame caspase-free pyroptosis as a wider doorway into immunogenic cell death therapy.
Catalog record
| CREATOR | Dan Zhao, Lingling Zhang, Yue Wen, Lianghui Cheng, Sidan Tian, Fanling Meng, Liang Luo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50400 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |