Unveiling Lactylation: A Novel Frontier in Cancer Stemness and Therapy
Ting Li, Hongyu Gu, Chang Liu, Yuesheng Lv, Feifei Li, Liang Liang, Jia Yi, Xuanyi Wang, Yi Zhun Zhu, Chuan Xu · 2026
Read Unveiling Lactylation: A Novel Frontier in Cancer Stemness and Therapy by Ting Li, Hongyu Gu, Chang Liu, Yuesheng Lv, Feifei Li, Liang Liang, Jia Yi, Xuanyi Wang, Yi Zhun Zhu, Chuan Xu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13393273.txt.
Description
Ting Li and nine co-authors review lactylation, a newly recognised chemical tag built from lactate that links tumour metabolism to gene control in cancer stem cells. Stem-like cancer cells drive relapse, spread, and drug resistance, and they sit at the crossing of metabolic rewiring and epigenetic tuning. Lactylation, the review argues, is the bridge: lactate pours out of sugar-hungry tumours, and its tag switches stemness programmes on.
The synthesis organises evidence along four fronts: keeping self-renewal alive, firing stemness signalling, adapting to hostile surroundings, and bending cell identity. It also maps the enzymes and indirect levers that write and erase the tag. Candidate drug targets and early preclinical wins are weighed against hard translation problems, from tag specificity to delivery. The authors offer the framework as a roadmap for attacking therapy resistance at its metabolic-epigenetic root.
Catalog record
| CREATOR | Ting Li, Hongyu Gu, Chang Liu, Yuesheng Lv, Feifei Li, Liang Liang, Jia Yi, Xuanyi Wang, Yi Zhun Zhu, Chuan Xu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63593 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |