Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke–Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling
Kyung‐Joo Seong, Sehoon Park, Sun‐Woong Bae, Daseul Kim, Jin Ho Lee, Won‐Seok Choi, Zee‐Yong Park, Ji‐Yeon Jung, Won‐Jae Kim · 2026
Read Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke–Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling by Kyung‐Joo Seong, Sehoon Park, Sun‐Woong Bae, Daseul Kim, Jin Ho Lee, Won‐Seok Choi, Zee‐Yong Park, Ji‐Yeon Jung, Won‐Jae Kim (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13393272.txt.
Description
Kyung-Joo Seong and eight colleagues tested the secretome of human dental pulp stem cells, the cocktail of factors those cells release, as a cell-free treatment for ischaemic stroke in mice. Stroke leaves lasting movement and thinking deficits through oxidative stress, inflammation, and neuron death. Protein profiling of the cocktail found antioxidant defenders and signals tied to calming the brain's immune cells.
Treatment shrank the dead tissue zone, cut neuron suicide and oxidative build-up, and quieted inflammatory signalling in cortex and hippocampus. Immune cells shifted toward a repair-associated profile, while new neuron birth, vessel remodelling, and synapse organisation in the hippocampus all improved. Behaviour followed the biology: coordination, spatial learning, contextual memory, and anxiety measures all recovered ground. The authors back the secretome as a candidate for post-stroke recovery therapy.
Catalog record
| CREATOR | Kyung‐Joo Seong, Sehoon Park, Sun‐Woong Bae, Daseul Kim, Jin Ho Lee, Won‐Seok Choi, Zee‐Yong Park, Ji‐Yeon Jung, Won‐Jae Kim |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 115487 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |