A High‐Loading Zn Single‐Atom Nanozyme Targets the Zn/HIF‐1α/GLUT1 Axis to Disrupt Glucose Metabolic Reprogramming and Remodel the Tumor Immune Microenvironment
Zhenxin Wang, Yuhang Tang, Ronghao Yue, Jingtao Xu, Yong Tao, Jie Chen, Shipeng Li, Guosheng Zhao, Jinfang Xue, Mingwei Sun, Fenglei Gao, Yunsheng Ou, Yang Wang · 2026
Read A High‐Loading Zn Single‐Atom Nanozyme Targets the Zn/HIF‐1α/GLUT1 Axis to Disrupt Glucose Metabolic Reprogramming and Remodel the Tumor Immune Microenvironment by Zhenxin Wang, Yuhang Tang, Ronghao Yue, Jingtao Xu, Yong Tao, Jie Chen, Shipeng Li, Guosheng Zhao, Jinfang Xue, Mingwei Sun, Fenglei Gao, Yunsheng Ou, Yang Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13393267.txt.
Description
Zhenxin Wang and twelve colleagues engineered a zinc single-atom nanozyme aimed at osteosarcoma, a bone cancer that spreads aggressively and resists standard therapy. Their starting insight links a lysosomal channel, TRPML1, through the oxygen sensor HIF-1-alpha and the glucose gate GLUT1, tying zinc handling inside cell recycling compartments to sugar metabolism. The platform carries dense zinc sites plus a glucose-burning enzyme, all drawn into those compartments.
Once inside, the particle devours glucose and acidifies its surroundings while its zinc sites generate corrosive oxygen species, jointly crushing the cell's reducing defences and triggering a sulfur-linked death programme. Zinc flooding and oxidative damage also rupture compartment membranes, firing an inflammatory death pathway. The double killing made tumour deaths more visible to the immune system and loosened the cancer's immune suppression in models.
Catalog record
| CREATOR | Zhenxin Wang, Yuhang Tang, Ronghao Yue, Jingtao Xu, Yong Tao, Jie Chen, Shipeng Li, Guosheng Zhao, Jinfang Xue, Mingwei Sun, Fenglei Gao, Yunsheng Ou, Yang Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 70615 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |