Neurodegeneration as an evolutionary trade-off: a biological constraint–aware therapeutic perspective
Seung Hyun Kim, Min-Young Noh, Matthew C Kiernan · 2026
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Description
Seung Hyun Kim's team suggests viewing nerve wasting as a change-over-time trade-off under living constraints, rather than solely as toxic protein clumping and picky nerve vulnerability. Clump-clearing and downstream-route treatments have shown limited, variable benefit, hinting broader context is missing.
Programs tuned for early-life life span, breeding, immune response, or neural performance may create lasting structural and functional limits. Ageing, stress, mutations, and exposures erode make-up room toward bounce-back burnout. Clashing multi-effect, where early benefits carry late costs, frames degeneration as tipping-point failure, pointing therapy toward preserving padding room rather than single targets alone.
Catalog record
| CREATOR | Seung Hyun Kim, Min-Young Noh, Matthew C Kiernan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 13 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |