Automatic Coregistration of High-Resolution MALDI-MSI and Raman Imaging Applied to Cardiac Tissue of Fabry Disease Mouse Models
Johann Dierks, Eike Ulrich Brockmann, Anahi-Paula Arias-Loza, Thomas Bocklitz, Peter Nordbeck, Kristina Lorenz, Elena Tolstik, Sven Heiles · 2026
Read Automatic Coregistration of High-Resolution MALDI-MSI and Raman Imaging Applied to Cardiac Tissue of Fabry Disease Mouse Models by Johann Dierks, Eike Ulrich Brockmann, Anahi-Paula Arias-Loza, Thomas Bocklitz, Peter Nordbeck, Kristina Lorenz, Elena Tolstik, Sven Heiles (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13393138.txt.
Description
Johann Dierks's team co-matched on its own high-detail MALDI mass scans imaging with Raman imaging on single heart tissue sections from Fabry disease mouse models. Early small-scale changes in low-mass compounds escape standard staining and gene work, yet multi-mode mapping of one section was technically demanding.
Mass scans imaging resolved mixed Gb3 fat forms down to five-micron pixels, showing sharply higher accumulation in mice combining Gal enzyme knockout with human synthase extra copies. Raman scope work at two-micron pixels mapped nuclei, tissue, collagen, and lipids for those genotypes, framing the lipid damage.
Catalog record
| CREATOR | Johann Dierks, Eike Ulrich Brockmann, Anahi-Paula Arias-Loza, Thomas Bocklitz, Peter Nordbeck, Kristina Lorenz, Elena Tolstik, Sven Heiles |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |