Sex-associated differences in routine inflammatory markers and neuromuscular ultrasound measurements in amyotrophic lateral sclerosis: a retrospective cross-sectional study
Jun Wang, Ying Wang, Tianhua Yang, Xinyi Yan, Jialei Luo, Shenghai Wu, Jiahui Tong, Min Zhao, Gaoyi Yang · 2026
Read Sex-associated differences in routine inflammatory markers and neuromuscular ultrasound measurements in amyotrophic lateral sclerosis: a retrospective cross-sectional study by Jun Wang, Ying Wang, Tianhua Yang, Xinyi Yan, Jialei Luo, Shenghai Wu, Jiahui Tong, Min Zhao, Gaoyi Yang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13393054.txt.
Description
Jun Wang and eight co-authors looked for sex differences in blood inflammation markers and ultrasound measures of nerves and muscles in people with amyotrophic lateral sclerosis. The disease weakens muscles by killing motor neurons. Records covered one hundred thirty-five patients. Routine blood counts and sedimentation rates were set beside ultrasound thickness and area measures, with statistics adjusting for age, body size, disease stage, and other illnesses.
Women scored lower on the standard function scale and seemed to progress faster in raw comparisons, while lung measures matched between sexes. After correction for multiple testing, women still showed lower neutrophil and monocyte counts, a higher sedimentation rate, and a thinner jaw muscle. In fully adjusted models women also showed a smaller median nerve area. The authors argue sex shapes the measurable biology of the disease and should feature in study design.
Catalog record
| CREATOR | Jun Wang, Ying Wang, Tianhua Yang, Xinyi Yan, Jialei Luo, Shenghai Wu, Jiahui Tong, Min Zhao, Gaoyi Yang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65172 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |