The key role of RANKL and OPG as molecular biomarkers in bone remodeling associated with different grafts regarding socket preservation: A systematic review
Firas A. Jamil, Saif S. Abdulrazzaq · 2026
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Description
Firas A Jamil and Saif S Abdulrazzaq reviewed studies of tooth socket preservation, the grafting done after extraction to hold jaw shape, tracking two molecular signals that steer bone rebuilding. One signal, RANKL, promotes bone-eating cells, while its decoy partner OPG blocks it, so their ratio hints at whether bone is being lost or gained. Twelve studies survived screening from an initial pool of just over three hundred.
Grafted sockets generally pushed the signals in the bone-friendly direction compared with ungrafted healing, and combined grafts did best. The lowest, most favourable ratio came from a biologically boosted graft of the patient's own bone, while a purely synthetic graft posted the highest ratio. The authors see promise in grafts pairing active agents with scaffolds, while warning that the ratio's value as a prediction tool remains unproven.
Catalog record
| CREATOR | Firas A. Jamil, Saif S. Abdulrazzaq |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63356 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |