Preclinical antitumor evaluation of a tetrahydrocannabinol and cannabidiol (1:6) cannabis extract in an MCF-7 xenograft model of estrogen receptor-positive breast cancer
Nuntana Meesiripan, Somchai Thanasitthichai, Suleeporn Sangrajrang, Nuntakan Suwanpidokkul, Piyaporn Prayakprom, Chatchada Bodhibukkana, Vipada Khaowroongrueng, Kankanit Suriyachan, Attasit Srisubat, Pattamaporn Surawongsin, Kasem Rattanapinyopituk, Siriwan Sakarin · 2026
Read Preclinical antitumor evaluation of a tetrahydrocannabinol and cannabidiol (1:6) cannabis extract in an MCF-7 xenograft model of estrogen receptor-positive breast cancer by Nuntana Meesiripan, Somchai Thanasitthichai, Suleeporn Sangrajrang, Nuntakan Suwanpidokkul, Piyaporn Prayakprom, Chatchada Bodhibukkana, Vipada Khaowroongrueng, Kankanit Suriyachan, Attasit Srisubat, Pattamaporn Surawongsin, Kasem Rattanapinyopituk, Siriwan Sakarin (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13392648.txt.
Description
Nuntana Meesiripan and eleven colleagues fed mice carrying human breast tumours an extract of cannabis blended at one part THC to six parts CBD, testing whether the mix could slow hormone-sensitive cancer. The animals carried grafts of MCF-7 cells, a standard model for oestrogen receptor positive disease. Groups of five mice received the extract by mouth for thirty days at three dose levels.
Every extract group grew smaller tumours than mice given plain sesame oil, and the highest dose shrank growth most. Tumour tissue showed more cells with the shrunken look of programmed death and lower scores for a marker of cell division than either control group. Blood counts stayed in normal ranges, although one liver enzyme rose, a caution the authors record alongside the promising tumour results.
Catalog record
| CREATOR | Nuntana Meesiripan, Somchai Thanasitthichai, Suleeporn Sangrajrang, Nuntakan Suwanpidokkul, Piyaporn Prayakprom, Chatchada Bodhibukkana, Vipada Khaowroongrueng, Kankanit Suriyachan, Attasit Srisubat, Pattamaporn Surawongsin, Kasem Rattanapinyopituk, Siriwan Sakarin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54657 |
| LICENSE | https://creativecommons.org/publicdomain/zero/1.0 |
| RIGHTS | CC0 |
| SOURCE | Europe PMC |