Comparative neuroprotective and cognitive effects of human umbilical cord mesenchymal stem cells, secretome, and exosomes in a rat model of pilocarpine-induced epilepsy
Sri Hastuti, Indra Bactiar, Yetty Ramli, Imran Imran, Rinaldi Idroes · 2026
Read Comparative neuroprotective and cognitive effects of human umbilical cord mesenchymal stem cells, secretome, and exosomes in a rat model of pilocarpine-induced epilepsy by Sri Hastuti, Indra Bactiar, Yetty Ramli, Imran Imran, Rinaldi Idroes (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13392634.txt.
Description
Sri Hastuti and colleagues compared three treatments drawn from umbilical cord tissue in rats with epilepsy triggered by the drug pilocarpine. One arm received the stem cells themselves. The other arms received the broth of substances the cells release, or tiny parcels called exosomes shed by the cells. Thirty male rats were split into five groups, including healthy and untreated epilepsy controls. Doses went into a vein on three occasions after seizures were induced.
Animals given whole stem cells showed the least hippocampal damage, close to healthy levels, and relearned a water maze fastest. Two marker genes tied to synapse health and support-cell function also returned to near-normal values only in that group. The released broth helped moderately, while exosomes helped least. The ranking suggests the cells themselves do more than any single product they shed, at least in this model.
Catalog record
| CREATOR | Sri Hastuti, Indra Bactiar, Yetty Ramli, Imran Imran, Rinaldi Idroes |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43820 |
| LICENSE | https://creativecommons.org/publicdomain/zero/1.0 |
| RIGHTS | CC0 |
| SOURCE | Europe PMC |