The Evolution of Knockdown Resistance: Genotypic and Phenotypic Insights Into Aedes aegypti Insecticide Resistance
Brook M Jensen, Alden S Estep, Silvie Huijben · 2026
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Description
Brook M Jensen, Alden S Estep, and Silvie Huijben traced how three mutations in a mosquito nerve channel combine to blunt insecticide sprays. They bred the yellow fever mosquito Aedes aegypti into six genetic combinations using parent strains from one Florida site, then dosed males and females with the spray chemical deltamethrin on the skin.
Mosquitoes carrying all three changes in double dose withstood over fifty times the dose that killed a standard laboratory strain, while other combinations fell in a lower band. Two resistant gene pairings behaved as partly recessive traits. Modelling showed the benefit of resistance rises and falls with dose and with how common the trait already is. Once body weight was accounted for, males matched females in resistance, which suggests males could serve in field monitoring.
Catalog record
| CREATOR | Brook M Jensen, Alden S Estep, Silvie Huijben |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51661 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |