Response to letter from Fontaine et al
Nupur Singh, Anna Conner, Zachary Nahmias · 2026
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Description
Nupur Singh, Anna Conner, and Zachary Nahmias reply to a letter from Fontaine and others about using dupilumab for delusional infestation, the fixed false belief that organisms infest the body. Their letter adds the new cases to their own earlier series of eleven patients. Across all reports they count seventeen people whose symptoms eased partly or fully on the drug.
Many patients had first cycled through antipsychotics, tetracycline antibiotics, nerve-calming drugs, and steroid creams without success. The authors float trying dupilumab earlier in the sequence, while noting its use here is off-label and untested in large trials. They also point to itch signalling through interleukin-31 as a possible mechanism, and suggest the interleukin-31 blocker nemolizumab, alone or combined, as a next subject for study.
Catalog record
| CREATOR | Nupur Singh, Anna Conner, Zachary Nahmias |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3093 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |