Distinguishing central precocious puberty from nonprogressive breast development: adiposity and DXA body composition
Daniela Fava, Amanda Casirati, Maria Grazia Calevo, Alessia Angelelli, Alessia Pepe, Nadia Gabriella Maiorano, Lucia Acquarone, Chiara Santucci, Claudia Caridi, Valentina Tosto, Marta Panciroli, Caterina Tedesco, Flavia Napoli, Anna Elsa Maria Allegri, Giuseppa Patti, Alessandro Naim, Roberto Gastaldi, Mohamad Maghnie, Natascia Di Iorgi · 2026
Read Distinguishing central precocious puberty from nonprogressive breast development: adiposity and DXA body composition by Daniela Fava, Amanda Casirati, Maria Grazia Calevo, Alessia Angelelli, Alessia Pepe, Nadia Gabriella Maiorano, Lucia Acquarone, Chiara Santucci, Claudia Caridi, Valentina Tosto, Marta Panciroli, Caterina Tedesco, Flavia Napoli, Anna Elsa Maria Allegri, Giuseppa Patti, Alessandro Naim, Roberto Gastaldi, Mohamad Maghnie, Natascia Di Iorgi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13392474.txt.
Description
Daniela Fava and many co-authors tackled a common clinic puzzle: telling true early puberty driven by the brain from breast development that will not progress, in girls who are also gaining weight. Extra fat can speed growth and bone ageing on its own, which blurs the usual physical clues. Their group covered one hundred girls plus sixteen prepubertal controls with obesity.
Height measures and bone age looked much the same across the two main groups, so they could not separate them. Hormone measures could, with luteinising hormone, follicle-stimulating hormone, oestradiol, and IGF-1 all clearly apart between groups. Body scans added one contrast, a higher waist-to-hip fat ratio in the nonprogressive group. Among heavier girls the growth clues blurred further, leaving blood tests as the dependable route.
Catalog record
| CREATOR | Daniela Fava, Amanda Casirati, Maria Grazia Calevo, Alessia Angelelli, Alessia Pepe, Nadia Gabriella Maiorano, Lucia Acquarone, Chiara Santucci, Claudia Caridi, Valentina Tosto, Marta Panciroli, Caterina Tedesco, Flavia Napoli, Anna Elsa Maria Allegri, Giuseppa Patti, Alessandro Naim, Roberto Gastaldi, Mohamad Maghnie, Natascia Di Iorgi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58934 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |