Protracted osilodrostat-induced pan-adrenal steroidogenic suppression and adrenal size reduction in Cushing disease
Yael Sofer, Rivka Kessner, Sher Matsri, Yona Greenman, Karen M Tordjman · 2026
Read Protracted osilodrostat-induced pan-adrenal steroidogenic suppression and adrenal size reduction in Cushing disease by Yael Sofer, Rivka Kessner, Sher Matsri, Yona Greenman, Karen M Tordjman (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13392468.txt.
Description
Yael Sofer and colleagues describe a man with hard-to-treat Cushing disease whose adrenal glands stayed switched off long after the drug osilodrostat was stopped. He had already had pituitary surgery twice plus focused radiation before starting the drug, which blocks a late step in cortisol production. Brief adrenal failure during dose changes is common with this medicine, but his course was very different.
After eighteen months of treatment his morning cortisol sat far below the reference range while pituitary drive ran extremely high, and salt-regulating and male hormone output were also suppressed. Replacement steroids were started, yet two and a half years later suppression persisted and the glands had shrunk. A check of ten earlier reports found nothing matching the full picture, suggesting recovery can take years.
Catalog record
| CREATOR | Yael Sofer, Rivka Kessner, Sher Matsri, Yona Greenman, Karen M Tordjman |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 20821 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |