Electrostatic bimodality of human cytosolic DNA sensor cGAS-dsDNA condensates revealed by millisecond flashing electrophoretic separation
Xiaoting Ling, Xingrui Song, Dapeng Zhang, Weiyi Lai, Cong Liu, Guibin Jiang, Qiang Zhao, Hailin Wang · 2026
Read Electrostatic bimodality of human cytosolic DNA sensor cGAS-dsDNA condensates revealed by millisecond flashing electrophoretic separation by Xiaoting Ling, Xingrui Song, Dapeng Zhang, Weiyi Lai, Cong Liu, Guibin Jiang, Qiang Zhao, Hailin Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13392432.txt.
Description
Xiaoting Ling's team built split-second flashing charge-field sorting to profile the charge landscape of bio droplets at near single-droplet detail. Charge patterns inside droplets regulate stability and function, yet exact electrical marks had been elusive.
Applied to droplets of the human DNA sensor cGAS with DNA, the rig found two zeta-charge groups from same components under same conditions, a surprise. Minus-charged droplets proved only open to the exo-enzyme TREX1, while positive ones were spared or boosted, and harmful cGAS forms disrupted this charge control, linking droplet bio-physics to inborn immune regulation.
Catalog record
| CREATOR | Xiaoting Ling, Xingrui Song, Dapeng Zhang, Weiyi Lai, Cong Liu, Guibin Jiang, Qiang Zhao, Hailin Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |