Epiblast lumenogenesis is not a mammalian-specific trait
Antonia Weberling, Natalia A Shylo, Hannah Wilson, Melainia McClain, Richard Kupronis, Alex Muensch, Suzannah A Williams, Florian Hollfelder, Paul A Trainor · 2026
Read Epiblast lumenogenesis is not a mammalian-specific trait by Antonia Weberling, Natalia A Shylo, Hannah Wilson, Melainia McClain, Richard Kupronis, Alex Muensch, Suzannah A Williams, Florian Hollfelder, Paul A Trainor (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13392392.txt.
Description
Antonia Weberling's team shows that early-disc lumen making, long seen as a mammal hallmark, also occurs in the veiled lizard, a scaled reptile. Early discs in reptiles were thought to form flat one-layer discs before layout and gut forming, based on bird models.
In lizards, a drawstring workings of concentric multi-cell actin rings tightened around the early disc to form a lumen before front-back layout, accompanied by a Wnt3A- and Brachyury-positive ring. Layout appeared independent of Cerberus and Lefty, giving lizard embryos human-like early shape despite three hundred million years of split.
Catalog record
| CREATOR | Antonia Weberling, Natalia A Shylo, Hannah Wilson, Melainia McClain, Richard Kupronis, Alex Muensch, Suzannah A Williams, Florian Hollfelder, Paul A Trainor |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |