Structural Modeling of Protein–DNA Interactions Underlying Genome Copy Number Variation in Nanoviruses
Aamir Lal, Myeonghwan Kwak, Muhammad Amir Qureshi, Sukchan Lee, Eui-Joon Kil · 2026
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Description
Aamir Lal and co-authors model, in 2026, how protein and DNA interactions may explain why the genome segments of nanoviruses accumulate at unequal levels. These multipartite plant viruses carry several genome pieces whose copy numbers form shifting formulas during infection, though all rely on one replication protein.
Focusing on a regulatory region of one segment of milk vetch dwarf virus, the team used structure-based computation to compare binding by replication and movement proteins from two nanoviruses under consistent conditions. Plant virus teams gain a clear claim to test. It may show how these split-genome viruses keep each part at its own level, year in and year out. The two source viruses share one host crop, which makes the match-up fair.
Catalog record
| CREATOR | Aamir Lal, Myeonghwan Kwak, Muhammad Amir Qureshi, Sukchan Lee, Eui-Joon Kil |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53493 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |