Sound effects: paradigm gene therapy approach installs hearing in children and adolescents born deaf
Juliane W. Schott, Michael Morgan, Axel Schambach · 2026
Read Sound effects: paradigm gene therapy approach installs hearing in children and adolescents born deaf by Juliane W. Schott, Michael Morgan, Axel Schambach (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13392261.txt.
Description
Juliane W Schott, Michael Morgan, and Axel Schambach comment, in 2026, on a landmark gene therapy trial that gave hearing to children born profoundly deaf. The CHORD study, published by Valayannopoulos and colleagues, tested an inner-ear infusion of a dual virus gene therapy called DB-OTO.
The trial was the first to set efficacy as the primary endpoint for hearing gene therapy and showed children hearing for the first time. Based on the findings, the therapy received a key regulatory designation in the United States. Gene therapy readers gain an expert reading of why this proof-of-principle matters beyond one rare deafness gene, as clinical proof that genetic deafness can be treated.
Catalog record
| CREATOR | Juliane W. Schott, Michael Morgan, Axel Schambach |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 16460 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |