Formation of topologically associated chromatin domains using quantum annealing
Tobias Kempe, S M Ali Tabei, Mohammad H Ansari · 2026
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Description
Tobias Kempe's team used quantum cooling to model how shape-linked DNA-packing domains form from epi-gene maps. These apart domains split active and inactive genome regions to regulate gene reading, but the link from one-axis epi-gene patterns to 3D folding stayed unclear.
Representing DNA packing as a spin system with DNA spools as single states, classical sampling methods struggle with clashes and dense links. The team placed an epi-gene Ising model in D-Wave quantum processors. Rather than exact domain sizes, the method reproduced pattern traits such as marker rates and DNA-spool links while generating domain-like shapes.
Catalog record
| CREATOR | Tobias Kempe, S M Ali Tabei, Mohammad H Ansari |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 74 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |