Anti-inflammatory potential of the CISACN adduct in LPS-induced murine models
Louise M. de Lima, Francisco A. A. F. Gadelha, Laércia K. D. Paiva Ferreira, Cosmo I. D. Vieira, João B. de Oliveira, Larissa A. M. Paiva Ferreira, Matheus Victor de Souza Laurentino, Bruno Vinícius da Silva Moura, Teresa Carolliny M. L. Rodrigues, Tayná R. Olegário, Luciana Scotti, Marcus T. Scotti · 2026
Read Anti-inflammatory potential of the CISACN adduct in LPS-induced murine models by Louise M. de Lima, Francisco A. A. F. Gadelha, Laércia K. D. Paiva Ferreira, Cosmo I. D. Vieira, João B. de Oliveira, Larissa A. M. Paiva Ferreira, Matheus Victor de Souza Laurentino, Bruno Vinícius da Silva Moura, Teresa Carolliny M. L. Rodrigues, Tayná R. Olegário, Luciana Scotti, Marcus T. Scotti (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13391798.txt.
Description
Louise M. de Lima's team tested the Morita-Baylis-Hillman adduct CISACN against acute lung injury in mice, a severe immune condition with no effective standard drug. The compound had shown calming activity in asthma and allergy models with low toxicity and good oral availability.
Mice given bacterial lipopolysaccharide by nose and treated orally with CISACN, most effectively at 12.5 milligrams per kilogram, showed less lung inflammation, lower TNF-alpha, interleukin-1 beta, and interleukin-6, less protein leakage, and milder tissue damage including oedema and haemorrhage. Computational and lab work tied the effect to TLR4 and p38 MAPK inhibition.
Catalog record
| CREATOR | Louise M. de Lima, Francisco A. A. F. Gadelha, Laércia K. D. Paiva Ferreira, Cosmo I. D. Vieira, João B. de Oliveira, Larissa A. M. Paiva Ferreira, Matheus Victor de Souza Laurentino, Bruno Vinícius da Silva Moura, Teresa Carolliny M. L. Rodrigues, Tayná R. Olegário, Luciana Scotti, Marcus T. Scotti |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |