PRBS Gas Challenges Reveal Impaired Chemoreflex and Cholinergic Dynamics in MCI
Suhaib Hashem, Stanley Yamashiro, Elizabeth Joe, Helena Chui, Vasilis Marmarelis · 2026
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Description
Suhaib Hashem and colleagues probe, in 2026, how the brain's blood oxygen control falters in mild cognitive impairment, using a cleverly patterned gas challenge. Standard assessments often miss time-dependent features of cerebrovascular regulation that may reveal hidden deficits.
Seventeen people took part: nine healthy adults and eight with mild impairment. None carried the ApoE4 risk gene. Each breathed gas mixes that swung between low oxygen and high carbon dioxide. The swings followed a set random-like code across three sittings. A scalp light sensor tracked brain oxygen. Staff also tracked blood pressure and the carbon dioxide in each out-breath. The team found weak reflex control in the group with mild impairment. Brain doctors gain a sharp test of blood flow control. It may flag vessel-linked harm long before a scan can.
Catalog record
| CREATOR | Suhaib Hashem, Stanley Yamashiro, Elizabeth Joe, Helena Chui, Vasilis Marmarelis |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36002 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |