Recent advances in bilirubin photoisomerization and photodegradation: in vitro and in vivo evidence for jaundice treatment
Larissa N Castro, Rafael Ravagnani, Iara R Tosta, Osmar V da Silva, Lucas D Dias · 2026
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Description
Larissa N Castro and co-authors review, in 2026, recent advances in how light breaks down bilirubin for treating newborn jaundice. Excess unconjugated bilirubin is among the commonest problems of term and preterm newborns and, at high levels, can cause irreversible brain damage.
Phototherapy is the standard treatment because light converts bilirubin into water-soluble products that leave the body without liver processing. The review gathers laboratory and living-system evidence on the conversion and degradation pathways and on wavelength tuning to speed them. Neonatal care researchers gain an updated mechanistic basis for improving light devices, rather than treating phototherapy as a settled, unchangeable standard.
Catalog record
| CREATOR | Larissa N Castro, Rafael Ravagnani, Iara R Tosta, Osmar V da Silva, Lucas D Dias |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46322 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |