Prediction of personalized therapeutic response in pediatric clivus chordoma: chemoresistance test
Sérgio Cavalheiro, Lorena Favaro Pavon, Caroline Brunetto de Farias, Flávia Borelli Nascimento, Martina Lichtenfels, Jessica Benigno Rodrigues, Natalia Dassi, Andreia Cappellano, Patrícia Alesssandra Dastoli, Thais Cristina de Souza Melo, Fernando Suzuki, Rodrigo Akira Watanabe, Isaque Hyung Tong Ki · 2026
Read Prediction of personalized therapeutic response in pediatric clivus chordoma: chemoresistance test by Sérgio Cavalheiro, Lorena Favaro Pavon, Caroline Brunetto de Farias, Flávia Borelli Nascimento, Martina Lichtenfels, Jessica Benigno Rodrigues, Natalia Dassi, Andreia Cappellano, Patrícia Alesssandra Dastoli, Thais Cristina de Souza Melo, Fernando Suzuki, Rodrigo Akira Watanabe, Isaque Hyung Tong Ki (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13391467.txt.
Description
Sérgio Cavalheiro's team used a working drug-response assay to guide treatment for a four-year-old with repeat spread clival chordoma, a rare, locally fast-moving tumour considered chemotherapy-stubborn in children. Tumour cell balls were tested ex vivo on the Bioverso rig.
The assay showed broad resistance with relative response to irinotecan, and an irinotecan course made marked medical and scan shrinkage of brain and lung lesions after three cycles, without severe harm. Response held for fourteen months, illustrating working exact cancer care for rare, stubborn child tumours where gene targets are scarce.
Catalog record
| CREATOR | Sérgio Cavalheiro, Lorena Favaro Pavon, Caroline Brunetto de Farias, Flávia Borelli Nascimento, Martina Lichtenfels, Jessica Benigno Rodrigues, Natalia Dassi, Andreia Cappellano, Patrícia Alesssandra Dastoli, Thais Cristina de Souza Melo, Fernando Suzuki, Rodrigo Akira Watanabe, Isaque Hyung Tong Ki |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |