Acquired genetic and cell-state changes in IDH-mutant glioma progression
Kevin C. Johnson, Avishay Spitzer, Frederick S. Varn, Masashi Nomura, Luciano Garofano, Tamrin Chowdhury, Anuja Lipsa, Linbin Zhang, Ester Calvo Fernández, Tanyeri Barak, A. Gulhan Ercan-Sencicek, Ayse Buket Peksen, Kevin J. Anderson, C. Mircea S. Tesileanu, Samirkumar B. Amin, Emre Kocakavuk, Dache · 2026
Read Acquired genetic and cell-state changes in IDH-mutant glioma progression by Kevin C. Johnson, Avishay Spitzer, Frederick S. Varn, Masashi Nomura, Luciano Garofano, Tamrin Chowdhury, Anuja Lipsa, Linbin Zhang, Ester Calvo Fernández, Tanyeri Barak, A. Gulhan Ercan-Sencicek, Ayse Buket Peksen, Kevin J. Anderson, C. Mircea S. Tesileanu, Samirkumar B. Amin, Emre Kocakavuk, Dache (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13391360.txt.
Description
Kevin C. Johnson's team charted how IDH-mutant gliomas evolve under treatment, joining single-nucleus gene readouts, DNA-packing access, and bulk gene reading from seventy-five tumours across thirty-five patients. These brain tumours arise in early to mid-adult life and nearly always recur, yet advance drivers stayed partly mapped.
Harmful cell states resembled normal glial-nerve development or a reactive support-cell state, with less mature cells rising alongside grade and alterations such as PDGFRA extra copies. Recurrence brought either going backward with gene chaos and growth-cycle change or support-cell expansion, two distinct change routes with treatment stakes.
Catalog record
| CREATOR | Kevin C. Johnson, Avishay Spitzer, Frederick S. Varn, Masashi Nomura, Luciano Garofano, Tamrin Chowdhury, Anuja Lipsa, Linbin Zhang, Ester Calvo Fernández, Tanyeri Barak, A. Gulhan Ercan-Sencicek, Ayse Buket Peksen, Kevin J. Anderson, C. Mircea S. Tesileanu, Samirkumar B. Amin, Emre Kocakavuk, Dache |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 97 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |