Single-cell insights into hepatic fibroblasts and stellate cells: heterogeneity in matrix remodelling in development, health, and disease
Sara Campinoti, Kavitha Kirubendran, Lai Wei, Maya Medic, Omkar Pravin Joshi, Luca Urbani · 2026
Read Single-cell insights into hepatic fibroblasts and stellate cells: heterogeneity in matrix remodelling in development, health, and disease by Sara Campinoti, Kavitha Kirubendran, Lai Wei, Maya Medic, Omkar Pravin Joshi, Luca Urbani (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13391356.txt.
Description
Sara Campinoti and co-authors review, in 2026, single-cell evidence that the liver's support cells are far more varied than their structural reputation suggests. Hepatic fibroblasts and stellate cells regulate liver development, daily balance, and disease, not merely scaffolding.
Drawing on single-cell and single-nucleus RNA sequencing, the review maps distinct subpopulations across fetal and adult liver, each with its own matrix-building programme and markers. The picture covers healthy tissue, development, and scarring disease. Liver researchers gain a cell-by-cell atlas of who remodels the liver matrix and when, guiding efforts to target only the subpopulations that drive fibrosis.
Catalog record
| CREATOR | Sara Campinoti, Kavitha Kirubendran, Lai Wei, Maya Medic, Omkar Pravin Joshi, Luca Urbani |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 101640 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |