The protective potential of intestinal Bifidobacterium-derived extracellular vesicles with unique lipid composition against blue light-induced damage in retinal cells
Wei-Hsuan Hsu, Pin-Hsuan Su, Hao-Yuan Chien, Tzu-Ming Pan, Bao-Hong Lee · 2026
Read The protective potential of intestinal Bifidobacterium-derived extracellular vesicles with unique lipid composition against blue light-induced damage in retinal cells by Wei-Hsuan Hsu, Pin-Hsuan Su, Hao-Yuan Chien, Tzu-Ming Pan, Bao-Hong Lee (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13391006.txt.
Description
Wei-Hsuan Hsu's team found that extracellular vesicles from the probiotic Bifidobacterium longum protect retinal cells from blue-light damage, via a gut-eye axis. Lipid profiling showed the vesicles rich in triacylglycerol, cholesteryl esters, and exact free fatty acids, a mix that eased entry into retinal pigment cells.
Vesicle treatment shielded ARPE-19 cells from oxidative death under blue light and tuned PI3K and mTOR signals to boost life span. The work suggests intestinal probiotic vesicles might one day guard eyes against light-induced damage, though human evidence remains ahead.
Catalog record
| CREATOR | Wei-Hsuan Hsu, Pin-Hsuan Su, Hao-Yuan Chien, Tzu-Ming Pan, Bao-Hong Lee |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |