Substantia Nigra MRI markers are lower in Alzheimer's disease and are linked to general cognitive function
Friedrich Krohn, Mousumi Sarkar, Hartmut Schütze, Panagiotis Iliopoulos, Lucía Penalba-Sánchez, Dorothea Hämmerer, Renat Yakupov, Falk Lüsebrink, Annika Spottke, Anja Schneider, Nina Roy, Enise Incesoy, Michael Heneka, Ingo Kilimann, Luca Kleineidam, Stefan J Teipel, Frederic Brosseron, Doreen Goerss, Wenzel Glanz, Matthias Schmid, Ayda Rostamzadeh, Michael Wagner, Klaus Fliessbach, Frank Olaf Jessen, Emrah Düzel, Matthew J Betts · 2026
Read Substantia Nigra MRI markers are lower in Alzheimer's disease and are linked to general cognitive function by Friedrich Krohn, Mousumi Sarkar, Hartmut Schütze, Panagiotis Iliopoulos, Lucía Penalba-Sánchez, Dorothea Hämmerer, Renat Yakupov, Falk Lüsebrink, Annika Spottke, Anja Schneider, Nina Roy, Enise Incesoy, Michael Heneka, Ingo Kilimann, Luca Kleineidam, Stefan J Teipel, Frederic Brosseron, Doreen Goerss, Wenzel Glanz, Matthias Schmid, Ayda Rostamzadeh, Michael Wagner, Klaus Fliessbach, Frank Olaf Jessen, Emrah Düzel, Matthew J Betts (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13390642.txt.
Description
Friedrich Krohn leads a 2026 imaging study asking whether a small midbrain region degenerates in Alzheimer's disease and tracks thinking ability. Post-mortem work shows varied damage in the substantia nigra alongside classic Alzheimer's pathology, but its link to symptoms during life was unclear.
Using a prospective German study of cognitive impairment and dementia, the team tested whether magnetic resonance measures of this region differ in Alzheimer's patients and relate to general cognition. The region's markers were lower in Alzheimer's disease and linked to cognitive function. Dementia researchers gain a candidate imaging signal outside the usual memory circuits, suggesting that Alzheimer's decline involves more brain systems than the classic ones.
Catalog record
| CREATOR | Friedrich Krohn, Mousumi Sarkar, Hartmut Schütze, Panagiotis Iliopoulos, Lucía Penalba-Sánchez, Dorothea Hämmerer, Renat Yakupov, Falk Lüsebrink, Annika Spottke, Anja Schneider, Nina Roy, Enise Incesoy, Michael Heneka, Ingo Kilimann, Luca Kleineidam, Stefan J Teipel, Frederic Brosseron, Doreen Goerss, Wenzel Glanz, Matthias Schmid, Ayda Rostamzadeh, Michael Wagner, Klaus Fliessbach, Frank Olaf Jessen, Emrah Düzel, Matthew J Betts |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47808 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |