TRIM15 Mediates ubiquitination of Paxillin to facilitate the progression of ovarian cancer
Jiaqi Xu, Tiantian Wu, Fei Wu, Yue Zhu, Meng Liu, Yan Zhang, Wenxin Gao, Weifeng Qian, Guannan Feng, Xiaoyan Huang, Xiaoxue Xi, Shunyu Hou · 2026
Read TRIM15 Mediates ubiquitination of Paxillin to facilitate the progression of ovarian cancer by Jiaqi Xu, Tiantian Wu, Fei Wu, Yue Zhu, Meng Liu, Yan Zhang, Wenxin Gao, Weifeng Qian, Guannan Feng, Xiaoyan Huang, Xiaoxue Xi, Shunyu Hou (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13390291.txt.
Description
Jiaqi Xu's team studied TRIM15, a tag-adding ligase protein, in ovarian cancer, where its role had been unclear despite links to other cancers. Tumour and normal tissue checks plus cell tests tested whether TRIM15 drives growth and spread by tagging the protein paxillin for tagging.
Ovarian tumours ran TRIM15 high, and switching off it slowed cancer cell growth and spread, while mass scans found paxillin among its binding partners. The work positions TRIM15-driven paxillin tagging as a workings of ovarian cancer advance and a lead treatment target. Blocking this route may slow spread in future work.
Catalog record
| CREATOR | Jiaqi Xu, Tiantian Wu, Fei Wu, Yue Zhu, Meng Liu, Yan Zhang, Wenxin Gao, Weifeng Qian, Guannan Feng, Xiaoyan Huang, Xiaoxue Xi, Shunyu Hou |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |