Small extracellular vesicle signaling and mitochondrial transfer reprogram T helper cell function in human asthma
Kenneth P Hough, Jennifer L Trevor, Shaheer Ahmad, Yong Wang, Balu K Chacko, Kayla F Goliwas, John G Strenkowski, Yuelong Liu, Joanna I Nowak, Eugene J Becker Jr, Young-il Kim, Renita Holmes, Nathaniel B Bone, Shia Vang, Alexandra Pritchard, Jay Chin, Sandeep Bodduluri, Veena B Antony, Sultan Tousif · 2026
Read Small extracellular vesicle signaling and mitochondrial transfer reprogram T helper cell function in human asthma by Kenneth P Hough, Jennifer L Trevor, Shaheer Ahmad, Yong Wang, Balu K Chacko, Kayla F Goliwas, John G Strenkowski, Yuelong Liu, Joanna I Nowak, Eugene J Becker Jr, Young-il Kim, Renita Holmes, Nathaniel B Bone, Shia Vang, Alexandra Pritchard, Jay Chin, Sandeep Bodduluri, Veena B Antony, Sultan Tousif (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13389491.txt.
Description
Kenneth P Hough's team found that tiny bubbles from airway control cells rewire helper T cells in asthma by carrying energy units. Small outside-cell bubbles run cell talk, but whether they carry energy units to feed asthma airway swelling was unknown.
Bubbles from asthma donors hit T cell sensors and moved energy units, driving antigen-matched firing toward Th17 and Th2 profiles through oxidant-linked NF-kB signals that blocking could blunt. A fission switch, DRP-1, loaded energy units into the bubbles, and nose transfer worsened allergic airway swelling in mice, showing a new asthma workings.
Catalog record
| CREATOR | Kenneth P Hough, Jennifer L Trevor, Shaheer Ahmad, Yong Wang, Balu K Chacko, Kayla F Goliwas, John G Strenkowski, Yuelong Liu, Joanna I Nowak, Eugene J Becker Jr, Young-il Kim, Renita Holmes, Nathaniel B Bone, Shia Vang, Alexandra Pritchard, Jay Chin, Sandeep Bodduluri, Veena B Antony, Sultan Tousif |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 95 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |