From Granulomas to Malignancy: Validating the Sydney System in a Tuberculosis-Endemic Landscape
Joyeeta Mandal, Sona Pathak, Arpana S Tirkey, Susruta Sen, Minakshi Karmakar, Nirmalya Banerjee, Sudip Roy, Nivedita Bhattacharjee · 2026
Read From Granulomas to Malignancy: Validating the Sydney System in a Tuberculosis-Endemic Landscape by Joyeeta Mandal, Sona Pathak, Arpana S Tirkey, Susruta Sen, Minakshi Karmakar, Nirmalya Banerjee, Sudip Roy, Nivedita Bhattacharjee (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13389425.txt.
Description
Joyeeta Mandal and co-authors validate, in 2026, a standard reporting system for lymph node needle samples in a region where tuberculosis is common. The Sydney System sorts these samples into five levels meant to guide care by the risk of cancer at each level.
The team reviewed 427 cases from two large hospitals in eastern India during 2025, with three pathologists scoring slides separately and without clinical details. Tissue results and a stain for tuberculosis bacteria served as the reference. Most samples came from neck nodes, and reactive, granulomatous, and necrotising patterns were common. Pathologists gain local accuracy figures, cancer risk by level, and agreement scores that show whether the system works fairly where tuberculosis often mimics cancer.
Catalog record
| CREATOR | Joyeeta Mandal, Sona Pathak, Arpana S Tirkey, Susruta Sen, Minakshi Karmakar, Nirmalya Banerjee, Sudip Roy, Nivedita Bhattacharjee |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37126 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |