Targeting arginine metabolism reverses bone immunosuppressive microenvironment and metastasis in ARID1A-deficient triple negative breast cancer
Shuangyue Pan, Jinyan Wang, Boya Wang, Fangqian Wang, Qingjian Chen, Tiantian Liu, Aima Zhang, Shenyuqi Wu, Bin Li, Hai Hu, Mengdi Yang, Zhonghua Tao, Xichun Hu · 2026
Read Targeting arginine metabolism reverses bone immunosuppressive microenvironment and metastasis in ARID1A-deficient triple negative breast cancer by Shuangyue Pan, Jinyan Wang, Boya Wang, Fangqian Wang, Qingjian Chen, Tiantian Liu, Aima Zhang, Shenyuqi Wu, Bin Li, Hai Hu, Mengdi Yang, Zhonghua Tao, Xichun Hu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13389217.txt.
Description
Shuangyue Pan's team traced how loss of the ARID1A gene helps triple-negative breast cancer spread to bone, a lethal turn whose workings were unclear. Patients with ARID1A-mutated tumours showed more bone metastases, and most mutations wiped out the protein.
Without ARID1A, arginine metabolism ramped up, raising ornithine and spermine, which expanded immune-suppressing myeloid cells in the bone marrow and eased metastasis. Blocking two pathway enzymes, ARG2 and ODC1, cut bone spread in models, pointing to a prevention strategy for this patient group. The work also clarifies why bone spread favours this subtype.
Catalog record
| CREATOR | Shuangyue Pan, Jinyan Wang, Boya Wang, Fangqian Wang, Qingjian Chen, Tiantian Liu, Aima Zhang, Shenyuqi Wu, Bin Li, Hai Hu, Mengdi Yang, Zhonghua Tao, Xichun Hu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 94 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |