Use of circulating tumour DNA to prospectively guide a switch from targeted to immune therapy in BRAF mutant advanced melanoma: the randomised phase II CAcTUS trial
Rebecca J. Lee, Dominic G. Rothwell, Nigel Smith, Shien Chow, Juan Delgado-SanMartin, Hitesh Mistry, Yvonne Sylvestre, Shih-Chieh Chiang, Harry Clarke, Gabriela Gremel, Avinash Gupta, Kimberley Hockenhull, Noel Kelso, Rohit Kochhar, Damian Mullan, Ruth Plummer, Patricio Serra, Heather Shaw, Holly Su · 2026
Read Use of circulating tumour DNA to prospectively guide a switch from targeted to immune therapy in BRAF mutant advanced melanoma: the randomised phase II CAcTUS trial by Rebecca J. Lee, Dominic G. Rothwell, Nigel Smith, Shien Chow, Juan Delgado-SanMartin, Hitesh Mistry, Yvonne Sylvestre, Shih-Chieh Chiang, Harry Clarke, Gabriela Gremel, Avinash Gupta, Kimberley Hockenhull, Noel Kelso, Rohit Kochhar, Damian Mullan, Ruth Plummer, Patricio Serra, Heather Shaw, Holly Su (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13389006.txt.
Description
Rebecca Lee and a large team of co-authors report a small trial in skin cancer care from two thousand twenty-six. The patients had advanced melanoma with a BRAF gene change. One drug type works fast but fades, while immune therapy works more slowly but lasts longer. The trial used a blood test to time a switch between them.
Twenty-one patients took part. In one group, care switched when the disease got worse. In the other, it switched when a blood marker fell by at least eighty percent. All key blood results came back within seven days, as planned. All patients on the fast drugs hit the marker fall. No new safety problems appeared in either group.
Catalog record
| CREATOR | Rebecca J. Lee, Dominic G. Rothwell, Nigel Smith, Shien Chow, Juan Delgado-SanMartin, Hitesh Mistry, Yvonne Sylvestre, Shih-Chieh Chiang, Harry Clarke, Gabriela Gremel, Avinash Gupta, Kimberley Hockenhull, Noel Kelso, Rohit Kochhar, Damian Mullan, Ruth Plummer, Patricio Serra, Heather Shaw, Holly Su |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |