Integrating multiplexing into confineable gene drives effectively overrides resistance in Anopheles stephensi
Mireia Larrosa-Godall, Lewis Shackleford, Matthew P. Edgington, Philip T. Leftwich, James C. Y. Luk, Joshua Southworth, Stewart Rosell, Jake T. Creasey, Jack M. Aked, Katherine Nevard, Alexander Dodds, Morgan Mckee, Eunice Adedeji, Estela Gonzalez, Joshua X. D. Ang, Michelle A. E. Anderson, Luke Alp · 2026
Read Integrating multiplexing into confineable gene drives effectively overrides resistance in Anopheles stephensi by Mireia Larrosa-Godall, Lewis Shackleford, Matthew P. Edgington, Philip T. Leftwich, James C. Y. Luk, Joshua Southworth, Stewart Rosell, Jake T. Creasey, Jack M. Aked, Katherine Nevard, Alexander Dodds, Morgan Mckee, Eunice Adedeji, Estela Gonzalez, Joshua X. D. Ang, Michelle A. E. Anderson, Luke Alp (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13388953.txt.
Description
Larrosa-Godall and a large team of co-authors hardened a mosquito gene drive in this study from twenty twenty-six. Gene drives push a genetic change through a population, here aimed at a malaria-carrying mosquito. The drive can fail when repair creates resistant target sites. The team tested using several guide RNAs at once against that failure.
Two multiplex designs were bred and checked in crosses. One packed four guides in a single construct, and the other spread them across separate constructs. A resistance change at one site did not cut the drive's copying rate for either design. Modeling then showed the fitness of drive carriers decides how long the drive lasts. The authors say multiplexing is a validated shield for split drives.
Catalog record
| CREATOR | Mireia Larrosa-Godall, Lewis Shackleford, Matthew P. Edgington, Philip T. Leftwich, James C. Y. Luk, Joshua Southworth, Stewart Rosell, Jake T. Creasey, Jack M. Aked, Katherine Nevard, Alexander Dodds, Morgan Mckee, Eunice Adedeji, Estela Gonzalez, Joshua X. D. Ang, Michelle A. E. Anderson, Luke Alp |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |