Identification of adducts formed between phosphatidylcholine and mustard agents
Matti A. Kjellberg, Noora-Kaisa Rantanen, Shishir Jaikishan, Susanne K. Wiedmer, Hanna Hakulinen · 2026
Read Identification of adducts formed between phosphatidylcholine and mustard agents by Matti A. Kjellberg, Noora-Kaisa Rantanen, Shishir Jaikishan, Susanne K. Wiedmer, Hanna Hakulinen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13388424.txt.
Description
Matti A Kjellberg and co-authors report in 2026 that sulphur and nitrogen mustards can bind directly to a common membrane lipid. Earlier work on these toxic blister agents focused mainly on changed proteins and DNA, while lipids had received little attention as possible markers of exposure.
Using high-resolution mass spectrometry, the team described the new compounds formed when the mustards reacted with the lipid in model membranes. They also detected the altered lipid in human plasma that had been mixed with very small amounts of sulphur mustard. For readers in toxicology and defence medicine, the findings point to a new kind of blood marker that could help confirm exposure after an incident.
Catalog record
| CREATOR | Matti A. Kjellberg, Noora-Kaisa Rantanen, Shishir Jaikishan, Susanne K. Wiedmer, Hanna Hakulinen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43694 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |