From bench to bedside: advancing our understanding of radioresistance in rectal cancer
Diogo Estêvão, Miguel da Cruz-Ribeiro, Diogo Coelho, Joana Lencart, Olga Sousa, Bruno Sarmento, Olivier de Wever, Maria J. Oliveira, Tânia Cruz · 2026
Read From bench to bedside: advancing our understanding of radioresistance in rectal cancer by Diogo Estêvão, Miguel da Cruz-Ribeiro, Diogo Coelho, Joana Lencart, Olga Sousa, Bruno Sarmento, Olivier de Wever, Maria J. Oliveira, Tânia Cruz (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13388369.txt.
Description
Diogo Estêvão and colleagues review why rectal cancers resist radiation in a 2026 article. Over half of cases still arrive at advanced stages, and up to two in five tumors resist or develop resistance to radiation. The review organizes mechanisms under the classic six Rs of radiobiology, from DNA repair to immune reactivation.
Tumor neighbors, including immune cells, macrophages, and fibroblasts, help build a resistant, spread-friendly niche after treatment. The authors propose a seventh R, reprogramming, for the metabolic rewiring that lets cells survive radiation. Lab models from spheroids to patient-derived organoids close the survey of tools for beating resistance.
Catalog record
| CREATOR | Diogo Estêvão, Miguel da Cruz-Ribeiro, Diogo Coelho, Joana Lencart, Olga Sousa, Bruno Sarmento, Olivier de Wever, Maria J. Oliveira, Tânia Cruz |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 94471 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |