Selective Small‐Molecule AdipoR1 Agonist 3‐Hydroxy Pterocarpan Salt (CDRI‐1709S) Ameliorates Skeletal Muscle Atrophy
Md. Rameez Moin, Shyamal Pal, Shubhrajyoti Das, Pallavi Awasthi, Anushka Talukdar, Akhilesh Kumar, Shruti Suhas Varode, Nikhil Nikolas, Shamima Khatoon, Madhav Nilkanth Mugale, Rajdeep Guha, Sabyasachi Sanyal, Atul Goel · 2026
Read Selective Small‐Molecule AdipoR1 Agonist 3‐Hydroxy Pterocarpan Salt (CDRI‐1709S) Ameliorates Skeletal Muscle Atrophy by Md. Rameez Moin, Shyamal Pal, Shubhrajyoti Das, Pallavi Awasthi, Anushka Talukdar, Akhilesh Kumar, Shruti Suhas Varode, Nikhil Nikolas, Shamima Khatoon, Madhav Nilkanth Mugale, Rajdeep Guha, Sabyasachi Sanyal, Atul Goel (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13387834.txt.
Description
Moin and colleagues reported a new drug candidate in 2026 that switches on AdipoR1, a receptor for the hormone adiponectin, to fight muscle wasting. Muscle loss rides along with many long-term diseases, yet no approved drug treats it. Earlier attempts stalled for lack of compounds that hit this receptor alone with a clean safety profile.
A screening test in engineered cells picked out the salt CDRI-1709S as a strong, selective switch for AdipoR1, active at very low doses. In mouse muscle cells it turned on energy and sugar-handling pathways, pushed young muscle cells to mature into fibers. Shielded fibers from wasting caused by steroids, inflammatory signals, and starvation, in part by silencing two wasting genes. In rats, it eased muscle loss after steroid treatment and after nerve cutting. The authors present it as a first-in-class lead for a condition with no drug options.
Catalog record
| CREATOR | Md. Rameez Moin, Shyamal Pal, Shubhrajyoti Das, Pallavi Awasthi, Anushka Talukdar, Akhilesh Kumar, Shruti Suhas Varode, Nikhil Nikolas, Shamima Khatoon, Madhav Nilkanth Mugale, Rajdeep Guha, Sabyasachi Sanyal, Atul Goel |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |