Mutant KRAS-driven selective mRNA translation reveals mechanisms and therapeutic vulnerabilities in cancer
Ankita Shrivastava, Eric Nels Pederson, Trang Uyen Nguyen, Jacky Chuen, Prathibha Mohan, Shivangi Pande, Ana Ruiz Toribio, Nicolas Lecomte, Jerry Melchor, John C McAuliffe, Paul M Grandgenett, Vinagolu K Rajasekhar, Kaila Nishikawa, Anna Knörlein, Yael David, Ian M Willis, Christine A Iacobuzio-Donahue, Zhengqing Ouyang, Kamini Singh · 2026
Read Mutant KRAS-driven selective mRNA translation reveals mechanisms and therapeutic vulnerabilities in cancer by Ankita Shrivastava, Eric Nels Pederson, Trang Uyen Nguyen, Jacky Chuen, Prathibha Mohan, Shivangi Pande, Ana Ruiz Toribio, Nicolas Lecomte, Jerry Melchor, John C McAuliffe, Paul M Grandgenett, Vinagolu K Rajasekhar, Kaila Nishikawa, Anna Knörlein, Yael David, Ian M Willis, Christine A Iacobuzio-Donahue, Zhengqing Ouyang, Kamini Singh (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13387423.txt.
Description
Ankita Shrivastava and a large team map selective protein production under mutant KRAS control in 2026 work. Mutant KRAS drives many cancers, yet how it steers which messages get translated stayed poorly defined. The team charted KRAS-dependent translation programs and how they remodel fast when KRAS is blocked.
A chosen message subset, including messages for the protein-making machinery itself, answered to KRAS in their data. Those messages share short, weakly folded leader regions and low-energy sequence motifs. Ribosomes piled up on the selected messages, which the authors read as a distinct control route apart from known mTOR and initiation factor paths.
Catalog record
| CREATOR | Ankita Shrivastava, Eric Nels Pederson, Trang Uyen Nguyen, Jacky Chuen, Prathibha Mohan, Shivangi Pande, Ana Ruiz Toribio, Nicolas Lecomte, Jerry Melchor, John C McAuliffe, Paul M Grandgenett, Vinagolu K Rajasekhar, Kaila Nishikawa, Anna Knörlein, Yael David, Ian M Willis, Christine A Iacobuzio-Donahue, Zhengqing Ouyang, Kamini Singh |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 81567 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |