Serine Ameliorates Cadmium‐Induced Testicular Injury by Regulating the PGAM1/PHGDH Signaling Pathway
Xueru Wang, Na Luo, Yonggang Ma, Hui Zou, Xishuai Tong, Jiaqiao Zhu, Ruilong Song, Hongyan Zhao, Zongping Liu · 2026
Read Serine Ameliorates Cadmium‐Induced Testicular Injury by Regulating the PGAM1/PHGDH Signaling Pathway by Xueru Wang, Na Luo, Yonggang Ma, Hui Zou, Xishuai Tong, Jiaqiao Zhu, Ruilong Song, Hongyan Zhao, Zongping Liu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13387075.txt.
Description
Xueru Wang and co-authors test whether the amino acid serine can protect mouse testes from cadmium, a widespread metal contaminant that impairs male fertility. Their 2026 study gives forty male mice plain water, serine, cadmium, or both in drinking water for eighteen weeks, then examines tissue, hormones, and metabolism.
Cadmium caused marked injury: lower testis weight, disturbed hormones, tissue damage, ion imbalance, oxidative stress, and inflammation, together with weakened barrier proteins between blood and testis. It also suppressed sugar breakdown and the testis's own serine production, switching off several enzymes in that pathway, and increased scarring and germ cell death. Adding serine substantially reversed these changes, restoring metabolic balance, antioxidant capacity, and tissue structure. The authors link the protection to two enzymes, PGAM1 and PHGDH, in serine metabolism, and propose serine as a candidate protective additive.
Catalog record
| CREATOR | Xueru Wang, Na Luo, Yonggang Ma, Hui Zou, Xishuai Tong, Jiaqiao Zhu, Ruilong Song, Hongyan Zhao, Zongping Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |