Alphavirus replicase and regulatory RNA elements in host interactions and viral vector engineering
Dan T. Boghici, Danni Yong, Silvia M. Vidal, GuanQun Liu · 2026
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Description
Dan T. Boghici and colleagues review the copying machinery of alphaviruses in a 2026 minireview. Tools built on these viruses have driven gene studies for nearly four decades. Interest has surged again because self-amplifying mRNA shots promise longer output from smaller doses than standard mRNA vaccines can give.
The review explains how the viral proteins and short conserved RNA parts work as a team to build new RNA and sway host cells. It then traces key steps in the growth of replicon tools and current ways to tune the copying parts and RNA layout. Gaps in basic knowledge that still block smart design close the piece.
Catalog record
| CREATOR | Dan T. Boghici, Danni Yong, Silvia M. Vidal, GuanQun Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65766 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |