Efficacy and safety of metastasis-directed therapy for oligometastatic cancer: a systematic review and meta-analysis of randomized controlled trials
David Chen, Ealia Khoshkish, Jane Jomy, Kristen Arnold, Joshua Yi, David Palma, Mitchell Liu, Xiang Y Ye, Zhihui Liu, Gabriel Boldt, Philip Wong, Srinivas Raman · 2026
Read Efficacy and safety of metastasis-directed therapy for oligometastatic cancer: a systematic review and meta-analysis of randomized controlled trials by David Chen, Ealia Khoshkish, Jane Jomy, Kristen Arnold, Joshua Yi, David Palma, Mitchell Liu, Xiang Y Ye, Zhihui Liu, Gabriel Boldt, Philip Wong, Srinivas Raman (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13386770.txt.
Description
David Chen's team pooled randomized trials of metastasis-directed therapy for oligometastatic cancer, in a 2026 systematic review and meta-analysis. Oligometastatic cancer means limited spread, usually five or fewer lesions, and local treatment of metastases may extend control, but evidence on benefit and harm was uncertain. The team searched three databases through June 2025 and pooled 37 records covering 3500 participants.
Upfront local therapy improved both progression-free and overall survival, while consolidation therapy improved progression-free survival only. Benefit differed by disease timing: new oligometastatic disease gained progression-free survival only, while recurrent disease gained both. Local therapy also raised odds of grade 2 or worse adverse events. The review supports adding local therapy to standard care, with attention to timing, patient choice, and long-term outcomes.
Catalog record
| CREATOR | David Chen, Ealia Khoshkish, Jane Jomy, Kristen Arnold, Joshua Yi, David Palma, Mitchell Liu, Xiang Y Ye, Zhihui Liu, Gabriel Boldt, Philip Wong, Srinivas Raman |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |