Product-Responsive Regulation of NADPH and Malonyl-CoA Allocation Enhances 3‑Hydroxypropionic Acid Production in Escherichia coli
Yuchan Kim, Kyung Hyun Cho, Chandran Sathesh-Prabu, Sung Kuk Lee · 2026
Read Product-Responsive Regulation of NADPH and Malonyl-CoA Allocation Enhances 3‑Hydroxypropionic Acid Production in Escherichia coli by Yuchan Kim, Kyung Hyun Cho, Chandran Sathesh-Prabu, Sung Kuk Lee (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13386637.txt.
Description
Yuchan Kim, Kyung Hyun Cho, and colleagues build a self-adjusting control circuit for bacterial chemical production in 2026 work. Their E. coli strain makes 3-hydroxypropionic acid, a platform chemical needing both NADPH and malonyl-CoA in balance. Static settings cannot track shifting cell states, so the circuit senses the product itself.
Once product builds up, the circuit jointly tunes cofactor regeneration and precursor allocation without outside input. The final strain reached a titer near 3 grams per liter, about five times the unregulated control strain. Yield per glucose rose by a similar factor, which supports product-responsive control as a modular tool.
Catalog record
| CREATOR | Yuchan Kim, Kyung Hyun Cho, Chandran Sathesh-Prabu, Sung Kuk Lee |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42200 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |