Engineering an Extremely Hybrid PKS for Adipic Acid Production
Sarah H. Klass, Zilong Wang, Nathan Lanclos, Mia Wesselkamper, Chenyi Li, Justin Baerwald, Allison Pearson, Makenzi Thomas, Weixi Hu, Matthias Schmidt, Yan Chen, Jennifer W. Gin, Christopher J. Petzold, Jay D. Keasling · 2026
Read Engineering an Extremely Hybrid PKS for Adipic Acid Production by Sarah H. Klass, Zilong Wang, Nathan Lanclos, Mia Wesselkamper, Chenyi Li, Justin Baerwald, Allison Pearson, Makenzi Thomas, Weixi Hu, Matthias Schmidt, Yan Chen, Jennifer W. Gin, Christopher J. Petzold, Jay D. Keasling (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13386636.txt.
Description
Sarah H. Klass and colleagues engineer a hybrid enzyme assembly line that makes adipic acid in 2026 work. Adipic acid is the nylon monomer usually made by industrial chemistry, not by polyketide synthases. Their design starts from a loading module that uniquely keeps a terminal acid group, opening diacid products.
Genes from five organisms were joined across six unnatural junctions into one working construct. It ran in two bacterial hosts, and further tuning of parts and host metabolism raised output. The authors present the system as a platform for other two-acid products that standard assembly lines cannot reach.
Catalog record
| CREATOR | Sarah H. Klass, Zilong Wang, Nathan Lanclos, Mia Wesselkamper, Chenyi Li, Justin Baerwald, Allison Pearson, Makenzi Thomas, Weixi Hu, Matthias Schmidt, Yan Chen, Jennifer W. Gin, Christopher J. Petzold, Jay D. Keasling |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53225 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |