Mast cell-specific receptor MrgprB2 selectively mediates oxaliplatin-induced neuropathic pain
Leo C Guan, Zhaoli Luo, Ruchita Kothari, Meilian Liu, Jieru Wan, Ankit Uniyal, Annie Y Guan, Qing Lin, Xinzhong Dong, Jing Liu · 2026
Read Mast cell-specific receptor MrgprB2 selectively mediates oxaliplatin-induced neuropathic pain by Leo C Guan, Zhaoli Luo, Ruchita Kothari, Meilian Liu, Jieru Wan, Ankit Uniyal, Annie Y Guan, Qing Lin, Xinzhong Dong, Jing Liu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13386573.txt.
Description
Leo Guan and nine co-authors find that one mast cell receptor drives pain from a specific cancer drug, in a research paper from 2026. Some chemotherapy drugs cause lasting nerve pain that limits treatment. Mast cells, a type of immune cell in skin, help drive this pain, but their exact role was unclear.
In mice, two drugs both drew mast cells into the paw, yet they released different substances. Mice lacking the receptor were protected from pain caused by oxaliplatin, but not from pain caused by paclitaxel. A natural blocker of the receptor gave the same split result. The authors say drug classes may need different pain treatments.
Catalog record
| CREATOR | Leo C Guan, Zhaoli Luo, Ruchita Kothari, Meilian Liu, Jieru Wan, Ankit Uniyal, Annie Y Guan, Qing Lin, Xinzhong Dong, Jing Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |