Deficient TRPM3-linked mitochondrial Ca2+ influx in natural killer cells associated with myalgic encephalomyelitis/chronic fatigue syndrome
Chandi Tabeth Magawa, Natalie Eaton-Fitch, Katsuhiko Muraki, Sonya Marshall-Gradisnik · 2026
Read Deficient TRPM3-linked mitochondrial Ca2+ influx in natural killer cells associated with myalgic encephalomyelitis/chronic fatigue syndrome by Chandi Tabeth Magawa, Natalie Eaton-Fitch, Katsuhiko Muraki, Sonya Marshall-Gradisnik (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13386572.txt.
Description
Chandi Tabeth Magawa, Natalie Eaton-Fitch, Katsuhiko Muraki, and Sonya Marshall-Gradisnik studied in 2026 calcium handling in immune cells from people with chronic fatigue syndrome, known as ME/CFS. Natural killer cells in these patients kill less well, and a calcium channel called TRPM3 is known to work poorly in them. The team asked what that fault does to calcium flow into the mitochondria, the cells' power units.
Using live-cell imaging, they found calcium entry into the cell sap was weaker and faster to fade in patient cells. Channel-driven calcium movement into both compartments was reduced. The results tie the channel fault to disturbed energy-side calcium signaling, adding a piece to the disease's mechanism.
Catalog record
| CREATOR | Chandi Tabeth Magawa, Natalie Eaton-Fitch, Katsuhiko Muraki, Sonya Marshall-Gradisnik |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |