p21-Activated Kinase (PAK) Group I‑Targeting Inhibitors Promote the Dimeric Conformation in Live Cells
Theresa A. L. Ehret, Benedict-Tilman Berger, Nicolai Raig, Felix Nowotka, Neele Manik, Viktoria Morasch, Andreas Krämer, Lewis Elson, Thiago Loreto Matos, Susanne Müller, Stefan Knapp, Martin P. Schwalm · 2026
Read p21-Activated Kinase (PAK) Group I‑Targeting Inhibitors Promote the Dimeric Conformation in Live Cells by Theresa A. L. Ehret, Benedict-Tilman Berger, Nicolai Raig, Felix Nowotka, Neele Manik, Viktoria Morasch, Andreas Krämer, Lewis Elson, Thiago Loreto Matos, Susanne Müller, Stefan Knapp, Martin P. Schwalm (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13386467.txt.
Description
Theresa A. L. Ehret and colleagues build live-cell assays for a family of signaling kinases in 2026 work. The six PAK kinases steer cell survival, movement, and shape, yet no assay could track drug binding for all forms inside cells. Light-based tags now report both drug engagement and pairing of the kinases in living cells.
Testing with those tools produced a surprise: group I PAK inhibitors appear to push the kinases into paired, dimeric forms. That finding changes how inhibitor action may be read in cells. The assay set gives drug designers a direct way to watch on-target effects across the whole family.
Catalog record
| CREATOR | Theresa A. L. Ehret, Benedict-Tilman Berger, Nicolai Raig, Felix Nowotka, Neele Manik, Viktoria Morasch, Andreas Krämer, Lewis Elson, Thiago Loreto Matos, Susanne Müller, Stefan Knapp, Martin P. Schwalm |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54296 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |