Host mature tRNAome as a decoding switch regulates antiviral and proviral responses
Xumin Ou, Xiaoming Lin, Jiayi Chen, Wenwen Yang, Di Sun, Shun Chen, Mafeng Liu, Dekang Zhu, Mingshu Wang, Renyong Jia, Sai Mao, Ying Wu, Qiao Yang, Shaqiu Zhang, Xinxin Zhao, Juan Huang, Bing Tian, Zhen Wu, Yu He, Qiuwei Pan, Anchun Cheng · 2026
Read Host mature tRNAome as a decoding switch regulates antiviral and proviral responses by Xumin Ou, Xiaoming Lin, Jiayi Chen, Wenwen Yang, Di Sun, Shun Chen, Mafeng Liu, Dekang Zhu, Mingshu Wang, Renyong Jia, Sai Mao, Ying Wu, Qiao Yang, Shaqiu Zhang, Xinxin Zhao, Juan Huang, Bing Tian, Zhen Wu, Yu He, Qiuwei Pan, Anchun Cheng (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13385959.txt.
Description
Xumin Ou and co-authors show that the cell's stock of mature transfer RNAs acts as a switch in virus fights, in this 2026 study. These small RNAs read the genetic code during protein building, for host and virus alike. The team found that an immune signal reshapes the stock, which then tunes how fast defense genes get translated.
Blocking that reshaping weakened the immune signal's power against hepatitis E virus. Hepatitis B virus, which dodges the defense response, still bends the stock its own way, favoring one arginine carrier. Blocking that carrier slowed the virus; boosting it sped viral growth in cells and mice.
Catalog record
| CREATOR | Xumin Ou, Xiaoming Lin, Jiayi Chen, Wenwen Yang, Di Sun, Shun Chen, Mafeng Liu, Dekang Zhu, Mingshu Wang, Renyong Jia, Sai Mao, Ying Wu, Qiao Yang, Shaqiu Zhang, Xinxin Zhao, Juan Huang, Bing Tian, Zhen Wu, Yu He, Qiuwei Pan, Anchun Cheng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 80 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |