Co-occurring clonal hematopoiesis exhibits strong selection and high leukemia risk
Kara M. Barnao, Aubrey K. Hubbard, Irenaeus C. C. Chan, Weiyin Zhou, Yasminka A. Jakubek, Giulio Genovese, Wendy S. W. Wong, Rebecca L. Kelly, Corey D. Young, Derek W. Brown, Wen-Yi Huang, Neal D. Freedman, Kristine Jones, Amy Hutchinson, Belynda Hicks, Duc Tran, Donna Arnett, Kathleen C. Barnes, Jo · 2026
Read Co-occurring clonal hematopoiesis exhibits strong selection and high leukemia risk by Kara M. Barnao, Aubrey K. Hubbard, Irenaeus C. C. Chan, Weiyin Zhou, Yasminka A. Jakubek, Giulio Genovese, Wendy S. W. Wong, Rebecca L. Kelly, Corey D. Young, Derek W. Brown, Wen-Yi Huang, Neal D. Freedman, Kristine Jones, Amy Hutchinson, Belynda Hicks, Duc Tran, Donna Arnett, Kathleen C. Barnes, Jo (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13385913.txt.
Description
Kara Barnao and a very large team of co-authors study people whose blood carries two kinds of age-related mutations at once, in a 2026 analysis. Each change alone, a mutated stem cell clone or a shuffled chromosome patch, raises blood cancer risk modestly.
Genomes from over half a million biobank participants were examined. The double state appeared in about one and a half percent of cancer-free people, far more often than chance allows. It was more common still after cancer treatment. One change type usually came first. People carrying both faced leukemia risks over forty times baseline, especially when the changes overlapped in the genome. The authors say double carriers form a high-risk group worth watching.
Catalog record
| CREATOR | Kara M. Barnao, Aubrey K. Hubbard, Irenaeus C. C. Chan, Weiyin Zhou, Yasminka A. Jakubek, Giulio Genovese, Wendy S. W. Wong, Rebecca L. Kelly, Corey D. Young, Derek W. Brown, Wen-Yi Huang, Neal D. Freedman, Kristine Jones, Amy Hutchinson, Belynda Hicks, Duc Tran, Donna Arnett, Kathleen C. Barnes, Jo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 74 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |