Manganese enhances macrophage bactericidal activity in mice with Staphylococcus aureus osteomyelitis via Sirt3-mitophagy axis
Xin Guan, Bingsheng Yang, Bowen Bai, Naiqian Cui, Muqi Wang, Jianwen Su, Xiaohu Wu, Chenghua Zhang, Hui Dai, Peng Zhao, Bin Yu, Bowei Wang · 2026
Read Manganese enhances macrophage bactericidal activity in mice with Staphylococcus aureus osteomyelitis via Sirt3-mitophagy axis by Xin Guan, Bingsheng Yang, Bowen Bai, Naiqian Cui, Muqi Wang, Jianwen Su, Xiaohu Wu, Chenghua Zhang, Hui Dai, Peng Zhao, Bin Yu, Bowei Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13385904.txt.
Description
Bone infections caused by staph bacteria often relapse because the germs hide inside immune cells meant to kill them. Xin Guan and co-authors showed in 2026 that manganese can re-arm those cells in mice.
The metal quiets a protein called Sirt3, which slows the cell's recycling of its own power plants. That pause lets reactive oxygen build up and kill the sheltered bacteria. Forcing Sirt3 back on erased the benefit, pinning the effect to this pathway. The team then built a targeted nano-carrier that delivered manganese to infected bone. Treated mice carried far fewer bacteria and suffered less bone damage.
Catalog record
| CREATOR | Xin Guan, Bingsheng Yang, Bowen Bai, Naiqian Cui, Muqi Wang, Jianwen Su, Xiaohu Wu, Chenghua Zhang, Hui Dai, Peng Zhao, Bin Yu, Bowei Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 126 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |