Tumor sialylation regulates G-CSF stability and promotes neutrophil-mediated immunosuppression in breast cancer
Stefan Mereiter, Gustav Jonsson, Tiago Oliveira, Ingrid-Judith Garberis, Johannes Helm, Markus Abeln, Ann-Kristin Jochum, Wolfram Jochum, Max J Kellner, Marek Feith, Vanessa Tkalec, Karolina Wasilewska, Jie Jiao, David Hoffmann, Lukas Emsenhuber, Felix Holstein, Anna C Obenauf, Guido Kroemer, Magali · 2026
Read Tumor sialylation regulates G-CSF stability and promotes neutrophil-mediated immunosuppression in breast cancer by Stefan Mereiter, Gustav Jonsson, Tiago Oliveira, Ingrid-Judith Garberis, Johannes Helm, Markus Abeln, Ann-Kristin Jochum, Wolfram Jochum, Max J Kellner, Marek Feith, Vanessa Tkalec, Karolina Wasilewska, Jie Jiao, David Hoffmann, Lukas Emsenhuber, Felix Holstein, Anna C Obenauf, Guido Kroemer, Magali (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13385813.txt.
Description
Stefan Mereiter's team shows tumor sugar coating shields breast cancer from immune attack, in a 2026 study. Breast cancer is the most common cancer in women, yet checkpoint inhibitors help only a minority. Tumor sialylation tracked inversely with T cell infiltration across breast cancer subtypes.
Blocking sialylation genetically or with drugs cut immunosuppressive neutrophil infiltration while raising CD8 effector and Tcf7 memory T cells in tumors. Sialylation lengthened the blood half-life of G-CSF, a driver of neutrophil suppression, and lowered MHC-I display. Disrupting sialylation sensitized resistant tumors to T cell killing and anti-PD-1 therapy, nominating a new immune target.
Catalog record
| CREATOR | Stefan Mereiter, Gustav Jonsson, Tiago Oliveira, Ingrid-Judith Garberis, Johannes Helm, Markus Abeln, Ann-Kristin Jochum, Wolfram Jochum, Max J Kellner, Marek Feith, Vanessa Tkalec, Karolina Wasilewska, Jie Jiao, David Hoffmann, Lukas Emsenhuber, Felix Holstein, Anna C Obenauf, Guido Kroemer, Magali |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 90 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |