Chromosome X dosage modulates development of aneuploidy in genetically diverse mouse embryonic stem cells
Alexander Stanton, Selcan Aydin, Daniel A Skelly, Tracy McGarr, Dylan Stavish, Kim Leonhard, Seth Taapken, Tenneille Ludwig, Erik McIntire, Matthew Pankratz, Anne Czechanski, Ted Choi, Steven P Gygi, Ivana Barbaric, Thomas Vierbuchen, Steven C Munger, Laura G Reinholdt, Martin F Pera · 2026
Read Chromosome X dosage modulates development of aneuploidy in genetically diverse mouse embryonic stem cells by Alexander Stanton, Selcan Aydin, Daniel A Skelly, Tracy McGarr, Dylan Stavish, Kim Leonhard, Seth Taapken, Tenneille Ludwig, Erik McIntire, Matthew Pankratz, Anne Czechanski, Ted Choi, Steven P Gygi, Ivana Barbaric, Thomas Vierbuchen, Steven C Munger, Laura G Reinholdt, Martin F Pera (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13385727.txt.
Description
Stanton and colleagues discover that having two X chromosomes protects embryonic stem cells against chromosome errors, in 2026 stem cell genetics research. Aneuploidy, gaining or losing chromosomes, plagues stem cell cultures and mirrors cancer biology. Mining RNA and protein data from lines derived from 170 Diversity Outbred mice, the team detected aneuploid subpopulations in 62 lines. They also found originally female XX lines that had lost one X, becoming XO during culture.
A lower proportion of XX lines were aneuploid than XY or XO lines. Single-cell data showed XY aneuploid lines expressed X-linked genes at less, and a culture study confirmed XY cells accumulate chromosome errors faster than XX cells. Protective mechanisms are proposed: XX lines keep two-cell-like cells, a genome-guarding state, and express more X-linked tumor suppressor genes, and they outcompete abnormal neighbors in mixed culture. Stanton links chromosome X dosage directly to genomic integrity.
Catalog record
| CREATOR | Alexander Stanton, Selcan Aydin, Daniel A Skelly, Tracy McGarr, Dylan Stavish, Kim Leonhard, Seth Taapken, Tenneille Ludwig, Erik McIntire, Matthew Pankratz, Anne Czechanski, Ted Choi, Steven P Gygi, Ivana Barbaric, Thomas Vierbuchen, Steven C Munger, Laura G Reinholdt, Martin F Pera |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 79 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |